Abstract #3390
Cerebellar connectomics provide new biomarkers in early multiple sclerosis
David Romascano 1,2 , Djalel-Eddine Meskaldji 2 , Guillaume Bonnier 1 , Samanta Simioni 3 , David Rotzinger 4 , Ying-Chia Lin 5 , Gloria Menegaz 5 , Alexis Roche 4,6 , Myriam Schluep 3 , Renaud Du Pasquier 3 , Jonas Richiardi 7,8 , Dimitri Van De Ville 7,8 , Alessandro Daducci 2 , Tilman J. Sumpf 9 , Jens Frahm 9 , Jean-Philippe Thiran 2,4 , Gunnar Krueger 1,6 , and Cristina Granziera 1,3
1
CIBM-AIT, cole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
2
Signal
Processing Laboratory (LTS5), cole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland,
3
Department
of Clinical Neurosciences, CHUV and UNIL, Lausanne,
Switzerland,
4
Department
of Radiology, University Hospital (CHUV), Lausanne,
Switzerland,
5
Department
of Computer Science, University of Verona, Verona,
Italy,
6
Advanced
Clinical Imaging Technology, Siemens Healthcare IM BM
PI, Lausanne, Switzerland,
7
School
of Engineering, cole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
8
Department
of Radiology and Medical Informations, University of
Geneva, Geneva, Switzerland,
9
Biomedizinische
NMR Forschungs GmbH, Max Planck Institute for
Biophysical Chemistry, Goettingen, Germany
The cerebellum is involved in multiple sclerosis (MS),
but its implication in early phases is still poorly
understood. We investigated structural and functional
cerebellar connectivity alterations in early and
minimally impaired MS patients, and their correlation to
patients clinical status. We reconstructed the
connectomes of 28 MS patients and 16 healthy controls
and performed network statistical analysis. Structural
connectivity was found to be altered independently from
cerebellar lesion count, volume and disease duration;
the microstructural properties of altered connections
correlated with patients motor and cognitive
performance. No topological reorganization or
compensatory mechanisms were observed at this stage.
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