Abstract #3391
COGNITIVE RESERVE IN MULTIPLE SCLEROSIS MODULATES HIPPOCAMPAL FUNCTIONAL CONNECTIVITY AND PROTECTS FROM MEMORY DEFICITS
Maria A. Rocca 1 , Alessandro Meani 1 , Paola Valsasina 1 , Gianna Riccitelli 1 , Mariaemma Rodegher 2 , Elisabetta Pagani 1 , Bruno Colombo 2 , Andrea Falini 3 , Giancarlo Comi 2 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Department of Neurology, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
3
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
We assessed the interaction between cognitive reserve,
memory impairment and hippocampal resting state (RS)
functional connectivity (FC) in multiple sclerosis (MS).
Memory impaired (MI) vs memory preserved (MP) patients
and controls had reduced hippocampal RS FC with the
bilateral caudate nucleus, and several region of frontal
and parietal lobes; whereas MP patients vs the other two
groups, had increased RS FC with the right cerebellum
and right orbital gyrus. Higher cognitive reserve index
were related to higher RS FC with the left orbital gyrus.
Cognitive reserve contributes to protect from memory
decline by modulating functional integrity of the
hippocampus.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
