COGNITIVE RESERVE IN MULTIPLE SCLEROSIS MODULATES HIPPOCAMPAL FUNCTIONAL CONNECTIVITY AND PROTECTS FROM MEMORY DEFICITS
Maria A. Rocca 1 , Alessandro Meani 1 , Paola Valsasina 1 , Gianna Riccitelli 1 , Mariaemma Rodegher 2 , Elisabetta Pagani 1 , Bruno Colombo 2 , Andrea Falini 3 , Giancarlo Comi 2 , and Massimo Filippi 1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
Department of Neurology, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
We assessed the interaction between cognitive reserve,
memory impairment and hippocampal resting state (RS)
functional connectivity (FC) in multiple sclerosis (MS).
Memory impaired (MI) vs memory preserved (MP) patients
and controls had reduced hippocampal RS FC with the
bilateral caudate nucleus, and several region of frontal
and parietal lobes; whereas MP patients vs the other two
groups, had increased RS FC with the right cerebellum
and right orbital gyrus. Higher cognitive reserve index
were related to higher RS FC with the left orbital gyrus.
Cognitive reserve contributes to protect from memory
decline by modulating functional integrity of the
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