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Abstract #3391

COGNITIVE RESERVE IN MULTIPLE SCLEROSIS MODULATES HIPPOCAMPAL FUNCTIONAL CONNECTIVITY AND PROTECTS FROM MEMORY DEFICITS

Maria A. Rocca 1 , Alessandro Meani 1 , Paola Valsasina 1 , Gianna Riccitelli 1 , Mariaemma Rodegher 2 , Elisabetta Pagani 1 , Bruno Colombo 2 , Andrea Falini 3 , Giancarlo Comi 2 , and Massimo Filippi 1

1 Neuroimaging Research Unit, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 2 Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy, 3 Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, MI, Italy

We assessed the interaction between cognitive reserve, memory impairment and hippocampal resting state (RS) functional connectivity (FC) in multiple sclerosis (MS). Memory impaired (MI) vs memory preserved (MP) patients and controls had reduced hippocampal RS FC with the bilateral caudate nucleus, and several region of frontal and parietal lobes; whereas MP patients vs the other two groups, had increased RS FC with the right cerebellum and right orbital gyrus. Higher cognitive reserve index were related to higher RS FC with the left orbital gyrus. Cognitive reserve contributes to protect from memory decline by modulating functional integrity of the hippocampus.

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