Abstract #3392
Temporal changes in regional atrophy in a large, relapsing multiple sclerosis cohort
Ponnada A Narayana 1 , Sushmita Datta 1 , Terrell D Staewen 2 , Stacey S Cofield 3 , Gary R Cutter 3 , Fred D Lublin 4 , and Jerry S Wolinsky 2
1
University of Texas Health Science Center at
Houston, Houston, Texas, United States,
2
University
of Texas Health Science Center at Houston, Texas, United
States,
3
University
of Alabama, Alabama, United States,
4
School
of Medicine at Mount Sinai, New York, United States
Longitudinal changes in regional brain atrophy were
investigated over three years in a large trial cohort of
RRMS subjects. Thalamic atrophy was evident within 6
months on study. Atrophy extended to multiple white and
gray matter structures with time in a structure
dependent manner. The lateral ventricular volume also
increased early. With time focal enlargement of sulci
was observed. The observed volume change is thought to
reflect tissue loss or neurodegeneration. Atrophy of
regional structures and increased CSF spaces may provide
more sensitive biomarkers than global change measures
for evaluating disease evolution and the effects of MS
therapies.
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