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Abstract #3392

Temporal changes in regional atrophy in a large, relapsing multiple sclerosis cohort

Ponnada A Narayana 1 , Sushmita Datta 1 , Terrell D Staewen 2 , Stacey S Cofield 3 , Gary R Cutter 3 , Fred D Lublin 4 , and Jerry S Wolinsky 2

1 University of Texas Health Science Center at Houston, Houston, Texas, United States, 2 University of Texas Health Science Center at Houston, Texas, United States, 3 University of Alabama, Alabama, United States, 4 School of Medicine at Mount Sinai, New York, United States

Longitudinal changes in regional brain atrophy were investigated over three years in a large trial cohort of RRMS subjects. Thalamic atrophy was evident within 6 months on study. Atrophy extended to multiple white and gray matter structures with time in a structure dependent manner. The lateral ventricular volume also increased early. With time focal enlargement of sulci was observed. The observed volume change is thought to reflect tissue loss or neurodegeneration. Atrophy of regional structures and increased CSF spaces may provide more sensitive biomarkers than global change measures for evaluating disease evolution and the effects of MS therapies.

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