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Abstract #3395

Nasal MOG ameliorates MRI brain pathology in progressive EAE

Hilit Levy-barazany 1 , Daniel Barazany 1,2 , Lindsay Puckett 3 , Shani Kanfi 1 , Nofit Borenstein-Auerbach 1 , Kayong Yang 3 , Jean Pierre S Peron 3 , Howard L Weiner 3 , and Dan Frenkel 1,4

1 Department of Neurobiology, Tel Aviv Unviersity, Tel Aviv, Israel, 2 CUBRIC School of Psychology, Cardiff University, Cardiff, United Kingdom, 3 Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 4 Sagol School of Neuroscience, Tel Aviv, Israel

MS is an autoimmune disease of the CNS in which pro-inflammatory processes that target self myelin lead to demyelination. We have shown that EAE model in non-obese diabetic mice leads to a chronic disease which is followed by brain lesion development that can be monitored by MRI. Here we examined whether immune responses induced by nasal MOG treatment affect clinical progression and demyelination in chronic progressive EAE, and evaluated the effect of the treatment by DTI and T1-Gd techniques. Our results demonstrate that MRI can monitor treatment of ongoing disease in this model for testing new therapies for MS.

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