Abstract #3394
Whole brain functional connectivity in clinically isolated syndrome with normal conventional brain MRI: a 5-year follow-up study
Yaou Liu 1 , Yunyun Duan 1 , Zhengjia Dai 2 , Ni Shu 2 , Yong He 2 , and Kuncheng Li 1
1
Xuanwu Hospital, Beijing, China,
2
Beijing
Normal University, Beijing, China
We demonstrate both functional impairment and
compensation in CIS, the earliest stage of MS, by
voxel-based resting-state fMRI. Furthermore, from CIS to
MS, the brain plasticity enhance especially in deep gray
matter, thus the alterations in CIS may be transient
prior to the onset of significant cortical
reorganization. Increased FCS in REC/ OLF/ACC and MFG
implies the brain reserve, which may predict the
conversion to MS.
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