Abstract #3398
Magnetization transfer ratio imaging in multiple sclerosis: superior selectivity of 3D balanced steady state free precession in comparison to 2D gradient echo
Michael Amann 1 , Till Sprenger 1,2 , Yvonne Naegelin 1 , Gabriela Kalt 2 , Stefano Magon 1 , Julia Reinhardt 1 , Pascal Kuster 2 , Ludwig Kappos 1 , Ernst-Wilhelm Radue 1,2 , Christoph Stippich 1 , and Oliver Bieri 1
1
University Hospital Basel, Basel, BS,
Switzerland,
2
Medical
Image Analysis Center (MIAC), Basel, BS, Switzerland
Magnetization transfer ratio (MTR) is an MRI marker for
demyelination in MS. In this study, a 3D-MTR technique
based on balanced steady-state free-precession (bSSFP)
is compared with a 2D-gradient-echo (GRE) MT sequence in
terms of MTR selectivity for different normal-appearing
brain structures and for lesions in 32 MS patients.
Spatial resolution was 1.3x1.3x1.3mm
3
(bSSFP)
and 1x2x4mm
3
(GRE)
yielding similar SNR and scan time. In bSSFP but not in
GRE, cortical-MTR was significantly higher than MTR of
accumbens, caudatus, and putamen; as well as white
matter MTR was higher than thalamus-MTR. Also, only in
bSFFP, cortical lesions’ MTR significantly predicted
EDSS.
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