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Abstract #3399

Lesion Effects on cerebellar peduncles DTI metrics in MS patients

Salem Hannoun 1,2 , Francoise Durand-Dubief 2,3 , Danielle Ibarrola 4 , Michele Cavallari 5 , Christian Confavreux 3 , Francois Cotton 2,6 , Charles RG Guttmann 5 , and Dominique Sappey-Marinier 2,4

1 OFSEP, University of Lyon, Bron, Rhones-Alpes, France, 2 CREATIS, University of Lyon, Lyon, Rhones-Alpes, France, 3 Service de Neurologie A, Pierre Wertheimer Neurological Hospital, Bron, Rhones-Alpes, France, 4 CERMEP-Imagerie du Vivant, Bron, Rhones-Alpes, France, 5 Brigham Hospital, Harvard University, Boston, Massachusetts, United States, 6 Service de Radiologie, Centre Hospitalier Lyon-Sud, Lyon, Rhones-Alpes, France

The goal of this cross-sectional study was to investigate the relative contribution of cerebellar peduncles microstructural integrity in determining disability in two groups of Multiple Sclerosis patients, with (WL) and without (NL) lesions, in the three cerebellar peduncles. Our results demonstrated significant alterations of diffusivity in the cerebellar white matter regions of all Multiple Sclerosis patients. These findings suggest the presence of microstructural damage of the cerebellum that probably contributed to the decreased motor and cognitive performances observed in Multiple Sclerosis patients, and particularly in patients with cerebellar peduncles lesions.

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