Abstract #3400
Test-retest reliability of whole brain myelin water fraction analysis using a spatially constrained multi-Gaussian algorithm on spiral T2 relaxometry data at 3 Tesla
Sneha Pandya 1 , Thanh D. Nguyen 1 , Mitchell A. Cooper 1 , Eve LoCastro 1 , Michael Dayan 1 , Susan A. Gauthier 2 , and Ashish Raj 1
1
Department of Radiology, Weill Cornell
Medical College, New York, NY, United States,
2
Department
of Neurology, Weill Cornell Medical College, New York,
NY, United States
Eleven healthy volunteers were scanned twice within the
same session at 3T using a whole brain fast T2prep 3D
spiral sequence. Myelin water fraction (MWF) maps were
extracted from these spirals using an automated
processing pipeline with the spatially constrained
multi-Gaussian algorithm. The inter-scan repeatability
for the test-retest reliability of whole brain MWF maps
was assessed. The whole brain MWF maps were highly
repeatable between the two scans with the mean
correlation coefficient R = 0.91 0.03 and mean
relative mean squared difference = 3.5 1.5% (n=11).
Bland-Altman plots reveal a negligible bias within
narrow limits of agreement.
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