Test-retest reliability of whole brain myelin water fraction analysis using a spatially constrained multi-Gaussian algorithm on spiral T2 relaxometry data at 3 Tesla
Sneha Pandya 1 , Thanh D. Nguyen 1 , Mitchell A. Cooper 1 , Eve LoCastro 1 , Michael Dayan 1 , Susan A. Gauthier 2 , and Ashish Raj 1
Department of Radiology, Weill Cornell
Medical College, New York, NY, United States,
of Neurology, Weill Cornell Medical College, New York,
NY, United States
Eleven healthy volunteers were scanned twice within the
same session at 3T using a whole brain fast T2prep 3D
spiral sequence. Myelin water fraction (MWF) maps were
extracted from these spirals using an automated
processing pipeline with the spatially constrained
multi-Gaussian algorithm. The inter-scan repeatability
for the test-retest reliability of whole brain MWF maps
was assessed. The whole brain MWF maps were highly
repeatable between the two scans with the mean
correlation coefficient R = 0.91 0.03 and mean
relative mean squared difference = 3.5 1.5% (n=11).
Bland-Altman plots reveal a negligible bias within
narrow limits of agreement.
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