Altered Microstructure of Normal Appearing White Matter in Multiple Sclerosis: Association with Neurological Disability
Maria Vittoria Spampinato 1 , Meaghan Neill 1 , Neal Hatch 1 , Jens H. Jensen 2 , Joseph Helpern 2 , and Ali Tabesh 2
Medical University of South Carolina,
Charleston, SC, United States,
University of South Carolina, SC, United States
We assessed correlations between measures of brain
tissue microstructure derived from diffusional kurtosis
imaging and neurological disability in forty-one
patients with multiple sclerosis. We found significant
correlations between the Expanded Disability Status
Scale (EDSS) and diffusion metrics of the normal
appearing white matter of the entire skeleton, genu and
body of the corpus callosum, and cortico-spinal tracts.
Quantitative imaging metrics may prove useful as
predictors of clinical outcome in multiple sclerosis and
have the potential to guide treatment.
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