Abstract #3405
Hypoperfusion of thalami is correlated with disability in MS patients - A statistical mapping analysis of whole brain pseudo-continuous arterial spin labeling MRI
Emilie Doche 1,2 , Angle Lecocq 1,3 , Adil Maarouf 1,3 , Guillaume Duhamel 1,3 , Virginie Callot 1,3 , Elisabeth Soulier 1,3 , Sylviane Confort-Gouny 1,3 , Audrey Rico 1,2 , Franoise Reuter 1,2 , Bertrand Audoin 1,2 , Jean Pelletier 1,2 , Jean-Philippe Ranjeva 1,3 , and Wafaa Zaaraoui 1,3
1
Aix-Marseille Universit, CNRS CRMBM UMR
7339, Marseille, France,
2
Pole
de Neurosciences Cliniques, APHM Hopital de la Timone,
Marseille, France,
3
Pole d'Imagerie mdicale,
CEMEREM, APHM Hopital de la Timone, Marseille cedex 5,
France
Increasing evidence suggests a microvascular
participation in Multiple Sclerosis (MS) injury, but
relationships between brain perfusion abnormalities and
disability have not been clearly demonstrated. Brain
perfusion of 23 MS patients and 16 healthy subjects was
assessed non-invasively by pseudoContinuous Arterial
Spin Labeling MRI at 3T. Cerebral blood flow (CBF) of
gray matter, white matter and T2lesions were extracted
and voxelwise analyses of CBF abnormalities were
performed. Perfusion abnormalities were found in
T2lesions and in the thalamus in MS patients (SPM8,
t-test p<0.005, k=20 FDR corrected p<0.05), and
correlated to disability (p=0.014, rho=-0.507).
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