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Abstract #3407

White matter tract integrity in Clinically Isolated Syndrome and early Relapsing-Remitting Multiple Sclerosis is related to lesional load

Domenico Aquino 1 , Paolo Confalonieri 2 , Laura Brambilla 2 , Valeria Elisa Contarino 1 , Marco Moscatelli 2 , Valentina Torri Clerici 2 , Greta Brenna 3 , Vincenza Fetoni 4 , Cristina Montomoli 5 , Carlo Antozzi 2 , Maria Grazia Bruzzone 1 , Renato Mantegazza 2 , and Alessandra Erbetta 1

1 Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, 2 Neuroimmunology and Neuromuscular Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, 3 Unit of Scientific Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy, 4 Department of Emergency Medicine and First Aid, Fatebenefratelli Hospital, Milan, Italy, 5 Department of Public Health, Experimental and Forensic medicine, University of Pavia, Pavia, Italy

Diffusion Tensor Imaging (DTI) can detect white matter (WM) microstructural damage and abnormalities of interconnecting tracts in Multiple Sclerosis. This study aims to investigate WM damage in the early stages of the disease by means of DTI in clinically isolated syndrome (CIS) and relapsing-remitting MS (RR-MS) within 3 years from the onset and to correlate DTI data with lesional load and disability. The study confirms the presence of WM damage in the very early stages of the disease. Significant differences were found between our CIS and RR groups and healthy controls. DTI metrics strongly correlated with the lesional load.

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