Abstract #3407
White matter tract integrity in Clinically Isolated Syndrome and early Relapsing-Remitting Multiple Sclerosis is related to lesional load
Domenico Aquino 1 , Paolo Confalonieri 2 , Laura Brambilla 2 , Valeria Elisa Contarino 1 , Marco Moscatelli 2 , Valentina Torri Clerici 2 , Greta Brenna 3 , Vincenza Fetoni 4 , Cristina Montomoli 5 , Carlo Antozzi 2 , Maria Grazia Bruzzone 1 , Renato Mantegazza 2 , and Alessandra Erbetta 1
1
Neuroradiology, Fondazione IRCCS Istituto
Neurologico Carlo Besta, Milan, Italy,
2
Neuroimmunology
and Neuromuscular Disorders Unit, Fondazione IRCCS
Istituto Neurologico Carlo Besta, Milan, Italy,
3
Unit
of Scientific Department, Fondazione IRCCS Istituto
Neurologico Carlo Besta, Milan, Italy,
4
Department
of Emergency Medicine and First Aid, Fatebenefratelli
Hospital, Milan, Italy,
5
Department
of Public Health, Experimental and Forensic medicine,
University of Pavia, Pavia, Italy
Diffusion Tensor Imaging (DTI) can detect white matter
(WM) microstructural damage and abnormalities of
interconnecting tracts in Multiple Sclerosis. This study
aims to investigate WM damage in the early stages of the
disease by means of DTI in clinically isolated syndrome
(CIS) and relapsing-remitting MS (RR-MS) within 3 years
from the onset and to correlate DTI data with lesional
load and disability. The study confirms the presence of
WM damage in the very early stages of the disease.
Significant differences were found between our CIS and
RR groups and healthy controls. DTI metrics strongly
correlated with the lesional load.
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