Abstract #3408
Functional relevance of cortical diffusion alterations in multiple sclerosis
Afaf S Elsarraj 1 , Daniel Rodriguez Gutierrez 1 , Hamza Alshuft 1 , Cris S Constantinescu 2 , Dorothee P Auer 1 , and Robert A Dineen 1
1
Radiological Sciences, Division of Clinical
Neurosciences, University of Nottingham, Nottingham,
United Kingdom,
2
Clinical
Neurology Group, Division of Clinical Neurosciences,
University of Nottingham, Nottingham, United Kingdom
Measurement of proton diffusion properties provides a
potential means to quantify cortical pathology in
multiple sclerosis (MS). We test the functional
relevance of cortical ultrastructure as measured by mean
diffusivity (MD) in MS. We perform cortical
surface-based mapping of partial volume corrected MD for
a cohort of 40 MS patients, with vertex-wise correlation
between MD and measures of clinical and cognitive
performance. Our results show statistically significant
differential patterns of functionally-relevant regional
cortical diffusion elevation between performance
measures in different functional domains in MS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
