Abstract #3409
Simultaneous Quantification of Permeability and Perfusion in Multiple Sclerosis Lesions
Govind Nair 1 , Katherine C Gao 1 , Colin D Shea 1 , Souheil J Inati 1 , Luca Massacesi 2 , and Daniel S Reich 1
1
NINDS, National Institutes of Health,
Bethesda, MD, United States,
2
Neuroscience,
Careggi University hospital, University of Florence,
Florence, Florence, Italy
The permeability and perfusion characteristics of MS
lesions change over time, as most acute enhancing lesion
stop enhancing in about 2 months. This cross-sectional
study used a double-echo T1-weighted gradient-echo EPI
sequence to simultaneously quantify perfusion and
permeability parameters in 16 MS patients. Eighteen
percent of the lesions studied had non-zero
permeability, even when no enhancement was appreciated
in the post-contrast T1-weighted images. These lesions
had a smaller plasma fraction compared to enhancing
lesions, suggesting longer lasting and more varying
dynamic changes to vasculature within lesions than
previously understood.
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