Abstract #3415
Altered functional connectivity in the brain default-mode network of earthquake survivors
Mingying Du 1 , Su Lui 1 , Keith Maurice Kendrick 2 , Xiaoqi Huang 1 , and Qiyong Gong 1
1
West China Hospital of Sichuan University,
Chengdu, Sichuan, China,
2
School
of Life Science and Technology, University of Electronic
Science and Technology of China, sichuan, China
Little is known about the long-term impact of traumatic
experience which may provide a better understanding of
consequences of trauma. We have applied graph theory
analysis of resting-state functional magnetic resonance
imaging to explore longitudinally the progressive impact
of severe stress on whole brain functional networks in
physically healthy survivors of the Wenchuan earthquake
within 25 days and 2-years after the earthquake. Results
show that while functional connectivity changes three
weeks after the disaster involved both frontal-limbic-striatal
and default-mode networks, at the 2-year follow up only
changes in the latter persisted, despite complete
recovery from high initial levels of anxiety.
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