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Abstract #3422

Regional analysis of DTI-FA in Milder TBI

Ramtilak Gattu 1 , Randall R Benson 2,3 , Zhifeng Kou 4 , Gabriela Trifan 3 , and Ewart Mark Haacke 4,5

1 Radiology, Wayne State University, Detroit, MI, United States, 2 Neurology and Radiology, Center for Neurologic Studies, Detroit, MI, United States, 3 Center for Neurologic Studies, NOVI, MI, United States, 4 Biomedical Engineering & Radiology, Wayne State University, Detroit, MI, United States, 5 The MRI Institute for Biomedical Research, Detroit, MI, United States

27 White matter brain regions were analyzed using a semi-automated regional approach, using the DTI scalar measures, Fractional Anisotropy (FA) for controls and traumatic brain injury groups, to identify the threshold for which these regions will show decreased FA. FA maps were created from diffusion images for eighty seven controls and one hundred and eighty TBI patients that underwent trauma imaging scanning protocol. TBI population showed a negative shift in the resulting FA histograms. These regions with decreased FA can be used to differentiate between normal controls and TBI subjects.

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