Abstract #3432
Abnormal intrinsic brain activity in temporomandibular disorder with centric relation-maximum intercuspation discrepancy: a resting state functional MRI study
Fei Li 1 , Shushu He 2 , Ning He 3 , Xiaoqi Huang 1 , Su Lui 1 , Qiyong Gong 1 , and Song Chen 2
1
Huaxi MR Research Center (HMRRC), Department
of Radiology, West China Hospital of Sichuan University,
Chengdu, Sichuan, China,
2
State
Key Laboratory of Oral Disease, Department of
Orthodontics, West China School of Stomatology, Sichuan
University, Chengdu, Sichuan, China,
3
Department
of Psychiatry, West China Hospital of Sichuan
University, Chengdu, Sichuan, China
Temporomandibular disorders (TMD) is a chronic pain
disorder characterized by pain in the masticatory
muscles and temporomandibular joint. Functional occlusal
theory considers centric relation-maximum intercuspation
(CR-MI) discrepancy as a potential factor for TMD and
believes that achieving CR-MI harmony after orthodontic
treatment reduces the risk of development of TMD.
Previous researches found TMD patients had abnormal
cerebral function, however, there are few studies
investigating the correlation between CR-MI discrepancy
characteristics and intrinsic cerebral function. The
present study aimed to explore abnormal brain function
in TMD patients with CR-MI discrepancy relative to
healthy controls using resting state functional MRI.
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