Abstract #3441
Longitudinal Functional MRI of Novel Tongue Strength Tasks: Before and After Partial Glossectomy in Tongue Cancer Patients
Kyung K Peck 1 , Ryan Branski 2 , Cathy Lazarus 3 , Andrei Holodny 4 , and Dennis Kraus 5
1
Memorial Sloan-Kettering Cancer Center, New
York, New York, United States,
2
New
York University, New York, United States,
3
Beth
Israel Medical Center, New York, United States,
4
Memorial
Sloan-Kettering Cancer Center, New York, United States,
5
North
Shore Health System, New York, United States
The current prospective study seeks to utilize fMRI to
identify and compare in partial glossectomy patients pre
and post-treatment activations during three tongue motor
tasks. Of interest, it was evident that, the amount of
activity in the tongue associated motor gyrus measured
in the pre scan is significantly reduced compared to the
scan after the tongue tumor resection. Based on the
hemodynamic response analysis, the time to peak (TTP)
and full width of half maximum (FWHM) of the IRF in the
tongue associated motor cortex was greater with all
tasks performed in the post scan. Similar to the
contralateral representation of the hand motor region,
this study suggests functionally what is seen clinically
with unilateral lesions causing tongue deviations. The
IRF analysis shows a consistent delay of TTP and
widening of the hemodynamic response across all tasks.
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