Three-dimensional macromolecular proton fraction mapping of the human cervical spinal cord

Macromolecular proton fraction (MPF) is a key parameter determining the magnetization transfer effect. Based on recent animal and clinical brain imaging studies, MPF has attracted significant interest as a biomarker of myelin. This study demonstrates the feasibility of quantitative MPF mapping of the human spinal cord in vivo. A recently published single-point MPF mapping method was adapted to the spinal cord imaging with improved time efficiency and SNR performance. 3D MPF maps of the human cervical spinal cord were obtained with 1x1x2 mm resolution and ~20 minutes scan time and demonstrated exceptionally strong contrast between white and gray matter structures.

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