Abstract #3452
Serial Assessment of Spinal Cord Injury in Monkeys by Multi-parametric MRI at 9.4T
Feng Wang 1,2 , Zhongliang Zu 1,2 , Huixin Qi 3 , Chaohui Tang 1 , John C. Gore 1,2 , and Li Min Chen 1,2
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
2
Radiology
Department, Vanderbilt University, Nashville, TN, United
States,
3
Psychology
Department, Vanderbilt University, TN, United States
Multi-parametric MRI methods such as chemical exchange
saturation transfer (CEST), magnetization transfer (MT)
and diffusion weighted imaging were applied to
characterize spinal cord injuries (SCI) and their
progression over time in anesthetized squirrel monkeys
up to 24 weeks after unilateral dorsal column lesion
(C4-C5). These methods are sensitive to the molecular
and cellular composition of tissues. Other than the
unusual high ADC and low MTR values observed for
abnormal volume (AV) around the lesion site in spinal
cord, significant variations of MTRasym were also
observed for AV at RF offsets ~3.5, 2.2 and 1.0 ppm
after lesion for the first time.
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