Abstract #3451
High-resolution, single-point, quantitative magnetization transfer (qMT) of the human spinal cord: application and validation in patients with MS
Alex K Smith 1,2 , Richard D Dortch 2,3 , Lindsey M Dethrage 2 , and Seth A Smith 2,3
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
3
Department
of Radiology and Radiological Sciences, Vanderbilt
University, Nashville, TN, United States
The spinal cord is responsible for mediating
neurological function between the brain and peripheral
nervous system, and is involved in many diseases such as
MS. Quantitative MRI can probe tissue microstructure,
but technical hurdles exist in the spinal cord due to
its small size and constant motion. qMT has been
reported to be sensitive to myelin changes, and has been
studied extensively in the brain, but suffers from long
scan times. Utilizing a single-point qMT methodology in
the cervical spinal cords of patients with MS, we
derived indices reflective of myelination that we show
are abnormal compared to healthy controls.
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