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Abstract #3456

In-vivo and ex-vivo assessment of spinal cord injury models of contusion injury and focal demyelination with frequency shift mapping

I-Wen Evan Chen 1 , Wolfram Tetzlaff 2,3 , Jie Liu 2 , Alexander Rauscher 1,4 , and Piotr Kozlowski 1,4

1 MRI Research Center, Vancouver, B.C., Canada, 2 International Collaboration On Repair Discoveries, Vancouver, B.C., Canada, 3 Zoology, University of British Columbia, Vancouver, B.C., Canada, 4 Radiology, University of British Columbia, Vancouver, B.C., Canada

Sources of strong white and gray matter (WM, GM) contrast obtained in gradient echo phase images of brain and spinal cord have been attributed to factors such as: iron, local bulk tissue magnetic susceptibility, and local tissue microstructure (and fiber orientation). Our results suggest that in-vivo assessment of (several) different spinal cord injuries is possible with frequency shift mapping due to its sensitivity to changes in tissue microstructure, local bulk tissue magnetic susceptibility, and presence of iron.

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