Abstract #3456
In-vivo and ex-vivo assessment of spinal cord injury models of contusion injury and focal demyelination with frequency shift mapping
I-Wen Evan Chen 1 , Wolfram Tetzlaff 2,3 , Jie Liu 2 , Alexander Rauscher 1,4 , and Piotr Kozlowski 1,4
1
MRI Research Center, Vancouver, B.C.,
Canada,
2
International
Collaboration On Repair Discoveries, Vancouver, B.C.,
Canada,
3
Zoology,
University of British Columbia, Vancouver, B.C., Canada,
4
Radiology,
University of British Columbia, Vancouver, B.C., Canada
Sources of strong white and gray matter (WM, GM)
contrast obtained in gradient echo phase images of brain
and spinal cord have been attributed to factors such as:
iron, local bulk tissue magnetic susceptibility, and
local tissue microstructure (and fiber orientation). Our
results suggest that in-vivo assessment of (several)
different spinal cord injuries is possible with
frequency shift mapping due to its sensitivity to
changes in tissue microstructure, local bulk tissue
magnetic susceptibility, and presence of iron.
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