Abstract #3459
Altered white matter tract integrity as a potential endophenotype of schizophrenia: a sibling study using automatic tract-specific analysis of the whole brain
Chen-Hao Wu 1,2 , Yu-Jen Chen 2 , Yun-Chin Hsu 2 , Yu-Chun Lo 2 , Tzung-Jeng Hwang 3 , Hai-Go Hwu 3 , Chung-Ming Chen 1 , and Wen-Yih Isaac Tseng 1,2
1
Institute of Biomedical Engineering,
National Taiwan University, Taipei, Taiwan, Taiwan,
2
Center
for Optoelectronic Medicine, National Taiwan University
College of Medicine, Taipei, Taiwan, Taiwan,
3
Department
of Psychiatry, National Taiwan University Hospital,
Taipei, Taiwan, Taiwan
Alteration of white matter tract integrity was reported
in siblings of schizophrenia patients in several studies
using voxel-based analysis (VBA). Some studies suggested
that tract-specific analysis (TSA) may be more specific
and reliable than VBA. However, manual tractography,
which is currently the main-stream approach, is time
consuming and not feasible for analyzing whole brain
tracts. In this study, we proposed a new method to
perform tract-specific analysis over the whole brain,
named tract-based automatic analysis (TBAA), using a
diffusion spectrum imaging (DSI) template and a tract
atlas. Using this method, we assessed the entire brain
white matter tracts and searched for potential white
matter tracts which could represent a possible
endophenotype of schizophrenia. We hypothesized that the
potential endophenotype of white matter tracts showed
altered integrity in both patients and siblings, and the
alteration had a gradation of differences from patients,
siblings to contols.
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