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Abstract #3460

Brain hyperactivation related to working memory in medication-naive boys with non-comorbid ADHD

Fei Li 1 , Yuanyuan Li 2 , Ning He 2 , Xiaoqi Huang 1 , Su Lui 1 , Lanting Guo 2 , and Qiyong Gong 1

1 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, chengdu, sichuan, China, 2 Department of Psychiatry, West China Hospital of Sichuan University, chengdu, sichuan, China

To our knowledge, the exploration of working memory-related brain activation using the CN-BT has not been previously reported in children and adolescents with ADHD. In addition to having activation within the sensory-motor pathways and the striato-cerebellum circuit similar to that of healthy controls with related visual-object and action cognitive strategies, the ADHD patients also showed task-negative activation in the fronto-cingulate-parietal network involved in working memory. Additionally, the higher activation of the bilateral globus pallidus and right hippocampus in ADHD patients compared to healthy controls revealed an important role in the pathophysiology of ADHD related to working memory.

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