Abstract #3461
Abnormal WM microstructural trajectories of autistic children from 2 to 7 years of age
Minhui Ouyang 1 , Hua Cheng 2 , Gaolang Gong 3 , Matt Mosconi 4,5 , John Sweeney 4,5 , Yun Peng 2 , and Hao Huang 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
Beijing
Children's Hospital, Capital Medical University,
Beijing, China,
3
State
key laboratory of Cognitive Neuroscience and Learning,
Beijing Normal University, Beijing, China,
4
Department
of Psychiatry, University of Texas Southwestern Medical
Center, Dallas, TX, United States,
5
Department
of Pediatrics, University of Texas Southwestern Medical
Center, Dallas, TX, United States
The majority of the studies using diffusion tensor
imaging (DTI) to investigate the white matter (WM)
integrity in the autistic brains have been focusing on
the age range from mid-childhood to adolescence. In this
study, we hypothesized that the growth trajectories of
the microstructural metrics of WM tracts from 2 to 7
years of age is different between autistic and normal
children, and these differences are widespread to
limbic, commissural, association and project tract
groups. To test these hypotheses, high quality DTI of
totally 51 children was acquired and trajectories of DTI
metrics of all WM voxels were examined.
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