Abstract #3463
White Matter Abnormality in Adolescents with Bipolar Disorder
Jonathan Dudley 1,2 , Melissa DelBello 1 , Stephen Strakowski 1,2 , Cal Adler 1,2 , Elizabeth Fugate 2 , Wen-Jang Chu 1,2 , and Jing-Huei Lee 1,3
1
Department of Psychiatry and Behavioral
Neuroscience, University of Cincinnati, Cincinnati,
Ohio, United States,
2
Center
for Imaging Research, University of Cincinnati,
Cincinnati, Ohio, United States,
3
Center
for Imaging Research, University of Cincinnati,
Cincinnati, O, United States
The white mater (WM) bioenergentic and phospholipid
metabolisms in adolescents with bipolar disoder were
investigated. The approach of this study used tissue
regression analysis of 31P MRSI data based on tissue
contents that were obtained by SPM5 segmentation of
MDEFT images. The results showed that, in addition to
the gray matter (GM), WM illustrated abnormality both in
bioenergentic and phospholipid metabolism in cerebrum,
particularly in the frontal lobe. No differences between
groups were found for phospholipids in GM for any
regions. Altered phospholipid metabolism in frontal lobe
WM suggests disruption of the anterior limbic network.
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