Abstract #3464
Effective connectivity analysis of visual-motor network in patients with schizophrenia
Nathan L Hutcheson 1 , Karthik R Sreenivasan 2 , Gopikrishna Deshpande 2,3 , David M White 1 , and Adrienne C Lahti 1
1
Department of Psychiatry and Behavioral
Neurobiology, The University of Alabama at Birmingham,
Birmingham, AL, United States,
2
AU
MRI Research Center, Department of Electrical and
Computer Engineering, Auburn University, Auburn, AL,
United States,
3
Department
of Psychology, Auburn University, Auburn, AL, United
States
Previous studies about connectivity within the
visual-motor network in patients with schizophrenia (SZ)
has shown altered functional connectivity, but critical
information regarding the directionality of these
connections are unknown. In this study we utilized fMRI
data analyzed using dynamic Granger causality to map the
connectivity within the visual-motor network in healthy
controls (HC) and SZ. We found that HC had stronger
unidirectional connections projecting from the visual
cortex to motor areas than SZ. Our results replicate
previous connectivity findings in HC and show novel
connectivity disruptions in SZ during the performance of
a visual-motor paradigm.
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