Abstract #3465
Brain Perfusion Differences in Autism Spectrum Disorders
Hua-Shan Liu* 1 , Gregory K. Bartley* 2 , John D. Herrington 2 , Benjamin E. Yerys 2 , John A. Detre 1 , and Robert T. Schultz 2
1
University of Pennsylvania, Philadelphia,
PA, United States,
2
The
Childrens Hospital of Philadelphia, Philadelphia, PA,
United States
Autism Spectrum Disorder (ASD) is associated with
abnormalities in brain areas associated with social
information processing, including multiple temporal lobe
regions. Although a number of ASD functional MRI studies
have established decreased temporal lobe activation in
contrasts of social information processing tasks versus
control, almost no studies have examined region-specific
differences in absolute cerebral blood flow (CBF).
Pseudo-continuous ASL data were collected in 33
participants with ASD and 26 typically developing
controls (TDCs). Decreased CBF in ASD was observed in
multiple temporal lobe areas associated with social
information processing including amygdala, fusiform
gyrus, and superior temporal gyrus. These results
suggest that core deficits in ASD may be mediated by
deficits in blood flow in and around brain areas
associated with social intelligence.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
