Brain Perfusion Differences in Autism Spectrum Disorders
Hua-Shan Liu* 1 , Gregory K. Bartley* 2 , John D. Herrington 2 , Benjamin E. Yerys 2 , John A. Detre 1 , and Robert T. Schultz 2
University of Pennsylvania, Philadelphia,
PA, United States,
Childrens Hospital of Philadelphia, Philadelphia, PA,
Autism Spectrum Disorder (ASD) is associated with
abnormalities in brain areas associated with social
information processing, including multiple temporal lobe
regions. Although a number of ASD functional MRI studies
have established decreased temporal lobe activation in
contrasts of social information processing tasks versus
control, almost no studies have examined region-specific
differences in absolute cerebral blood flow (CBF).
Pseudo-continuous ASL data were collected in 33
participants with ASD and 26 typically developing
controls (TDCs). Decreased CBF in ASD was observed in
multiple temporal lobe areas associated with social
information processing including amygdala, fusiform
gyrus, and superior temporal gyrus. These results
suggest that core deficits in ASD may be mediated by
deficits in blood flow in and around brain areas
associated with social intelligence.
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