Abstract #3466
Abnormal grey matter volume correlates with executive dysfunction in attention deficit hyperactivity disorder
Fei Li 1 , Ning He 2 , Yuanyuan Li 2 , Xiaoqi Huang 1 , Su Lui 1 , Lanting Guo 2 , and Qiyong Gong 1
1
Huaxi MR Research Center (HMRRC), Department
of Radiology, West China Hospital of Sichuan University,
Chengdu, Sichuan, China,
2
Department
of Psychiatry, West China Hospital of Sichuan
University, Chengdu, Sichuan, China
Attention deficit hyperactivity disorder (ADHD) is
characterized by age-inappropriate degrees of
inattention, hyperactivity and impulsivity. The specific
neuropsychological dysfunction underlying atypical brain
structure remains poorly understood. ADHD patients often
exhibit deficiencies in cognitive function. A link to
executive dysfunction is central to models involving
aberrant fronto-subcortical circuits; however, there has
been much debate about what core deficit of brain
structure might cause the impairments of ADHD. The aims
of the present study were to define, in children and
adolescents with ADHD, abnormalities of grey matter
volume, and to explore the association between these
alterations of brain structure and executive
dysfunction.
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