Abstract #3467

Altered cingulate functional circuits in adolescents with Internet addiction disorder revealed by resting-state fMRI

Fuchun Lin ¹ , Yasong Du ² , Yan Zhou ³ , Jianrong Xu ³ , and Hao Lei ¹

¹ State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics & Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China, ² Shanghai Mental Health Center, Jiao Tong University Medical School, Shanghai, Shanghai, China, ³ RenJi Hospital, Jiao Tong University Medical School, Shanghai, Shanghai, China

Resting-state functional connectivity (rsFC) was used to investigate seven resting-state functional networks associated with cingulate subregions (sACC, oACC, dACC, MCC, dPCC, vPCC and RSC) in adolescent students with Internet addiction disorder (IAD). These functional networks involve multiple cortical, subcortical, insula, parietal regions that are known to engage in emotional generation and processing, executive attention, decision making, and cognitive control. Although both the IAD subjects and controls show similar FC patterns for seven cingulate subregions, however, IAD had altered connectivity strength for every cingulate subregion except the RSC. Moreover, the strength of rsFC between dPCC and PHG was negatively correlated with SCARED, and the strength of rsFC between vPCC and SFG was negatively correlated with YIAS. Our findings suggest that rsFC may be used as a qualified biomarker to understand the underlying neural mechanisms or to evaluate the effectiveness of specific early interventions in IAD.

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