Aberrant resting-state functional connectivity in a genetic rat model of depression
Daniele Procissi 1 , Kathleen Anne Williams 1 , Neha Mehta 2,3 , Lei Wang 1,2 , and Eva E redei 2,3
Radiology, Northwestern University, Chicago,
Illinois, United States,
and Behavioral Sciences, Northwestern University,
Chicago, Illinois, United States,
and Helen Asher Center for the Study of Depressive
Disorders, Northwestern University, Chicago, Illinois,
Major depressive disorder (MDD) is a common disease with
unknown etiology. Functional connectivity networks have
been found to be dysregulated in depression, but the
cause of these anomalies has not yet been elucidated.
Animal models of MDD have topological properties of
functional connectivity which are conserved between
humans and rodents. This study aims at identifying
aberrant connectivity patterns using fMRI using a
genetic rat model of MDD . By comparing the MDD model
Wistar More Immobile with its control Wistar Less
Immobile we aim at pinpointing differences in
connectivity which reflect the genetic and behavior
findings previously reported in literature.
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