Meeting Banner
Abstract #3474

Widespread disruption of white matter myelin revealed from a relatively large scale of bipolar DTI study

Austin Ouyang 1 , Benson Irungu 2 , Marsal Sanches 2 , Hao Huang 1 , and Jair C Soares 2

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 University of Texas Health Science Center at Houston, Houston, TX, United States

Bipolar disorder (BD) is one of the most potentially disabling mental disorders, associated with high rates of psychological suffering, marked functional and economic impact, and elevated risk of suicide. Over the last two decades, neuroimaging studies have provided valuable information on the pathophysiology of this condition. In this study, DTI has been applied to a relatively large cohort of patient group (49 patients and 28 age-matched controls) to find if disruption of WM is widespread covering four functionally distinct tract groups and if myelin loss constitutes the major neuropathology associated with BD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here