Abstract #3474
Widespread disruption of white matter myelin revealed from a relatively large scale of bipolar DTI study
Austin Ouyang 1 , Benson Irungu 2 , Marsal Sanches 2 , Hao Huang 1 , and Jair C Soares 2
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, TX, United
States,
2
University
of Texas Health Science Center at Houston, Houston, TX,
United States
Bipolar disorder (BD) is one of the most potentially
disabling mental disorders, associated with high rates
of psychological suffering, marked functional and
economic impact, and elevated risk of suicide. Over the
last two decades, neuroimaging studies have provided
valuable information on the pathophysiology of this
condition. In this study, DTI has been applied to a
relatively large cohort of patient group (49 patients
and 28 age-matched controls) to find if disruption of WM
is widespread covering four functionally distinct tract
groups and if myelin loss constitutes the major
neuropathology associated with BD.
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