Abstract #3475
The relation of brain matter volume and myo-inositol to gamma-glutamyltransferase and BMI in patients with alcohol dependence and healthy control subjects
Gabriele Ende 1 , Markus Sack 1 , Julia van Eijk 1 , Traute Demirakca 2 , Wofgang Weber-Fahr 2 , Derik Hermann 3 , Ulrich Frischknecht 4 , and Karl Mann 3
1
NeuroImaging, Central Institute of Mental
Health, Mannheim, Germany,
2
NeuroImaging,
Central Institute of Mental Health, Germany,
3
Addictive
Behaviour and Addiction Medicine, Central Institute of
Mental Health, Mannheim, Germany,
4
Addictive
Behaviour and Addiction Medicine, Central Institute of
Mental Health, Germany
MRI and MRS data of 38 alcohol dependent patients on the
first day of withdrawal and 41 healthy controls were
analyzed regarding their relation to
gamma-glutamyltransferase (gGT) and the body mass index
(BMI). Our BMI findings corroborate recent reports on GM
volume and BMI: BMI correlates negatively with brain
volume in healthy controls but shows a positive
correlation in alcohol dependent patients.We further
find a negative correlation of gGT with GM and a
positive correlation with mI in both groups. To the best
of our knowledge this is the first report of a positive
correlation of mI with gGT.
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