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Abstract #3477

Alteration of White Matter Tract Integrity in Adults with ADHD as Compared to Healthy Adults: A Diffusion Spectrum Imaging Study Using Whole Brain Tract-Based Automatic Analysis

Li-Kuang Yang 1,2 , Yu-Jen Chen 3 , Issac Wen-Yih Tseng 3,4 , and Susan Shur-Fen Gau 2,4

1 Department of Psychiatry, National Defense Medical Center Tri-Service General Hospital, Beitou Branch, Taipei, Taipei, Taiwan, 2 Department of Psychiatry, National Taiwan University Hospital, Taipei, Taipei, Taiwan, 3 Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan, 4 Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan

Attention deficit/hyperactivity disorder (ADHD) lasts to adulthood with recent evidence of widespread brain abnormalities. Diffusion imaging studies have revealed disturbed white matter microstructure integrity in several brain regions. As the first study to examine the integrity using diffusion spectrum imaging in adults with ADHD, we aimed to identify the fiber tracts which can distinguish adults with ADHD from healthy adults. Using a novel tract-based automatic analysis among 47 adults with ADHD and 48 healthy controls, 13 tracts, mainly located in fornix, corpus callosum, fronto-striatal tracts, and thalamo-cortical tracts could be identified. The two groups were found to have differential neurocorrelates with correlation and prediction to attention performance.

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