Abstract #3477
Alteration of White Matter Tract Integrity in Adults with ADHD as Compared to Healthy Adults: A Diffusion Spectrum Imaging Study Using Whole Brain Tract-Based Automatic Analysis
Li-Kuang Yang 1,2 , Yu-Jen Chen 3 , Issac Wen-Yih Tseng 3,4 , and Susan Shur-Fen Gau 2,4
1
Department of Psychiatry, National Defense
Medical Center Tri-Service General Hospital, Beitou
Branch, Taipei, Taipei, Taiwan,
2
Department
of Psychiatry, National Taiwan University Hospital,
Taipei, Taipei, Taiwan,
3
Center
for Optoelectronic Biomedicine, National Taiwan
University College of Medicine, Taipei, Taiwan,
4
Graduate
Institute of Brain and Mind Sciences, National Taiwan
University College of Medicine, Taipei, Taiwan
Attention deficit/hyperactivity disorder (ADHD) lasts to
adulthood with recent evidence of widespread brain
abnormalities. Diffusion imaging studies have revealed
disturbed white matter microstructure integrity in
several brain regions. As the first study to examine the
integrity using diffusion spectrum imaging in adults
with ADHD, we aimed to identify the fiber tracts which
can distinguish adults with ADHD from healthy adults.
Using a novel tract-based automatic analysis among 47
adults with ADHD and 48 healthy controls, 13 tracts,
mainly located in fornix, corpus callosum,
fronto-striatal tracts, and thalamo-cortical tracts
could be identified. The two groups were found to have
differential neurocorrelates with correlation and
prediction to attention performance.
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