Abstract #3478
The effect of dopaminergic drugs on reward prediction error and novelty processing in ADHD
Arjun Sethi 1 , Duncan Fowler 1 , Jessica Eccles 1 , Valerie Voon 2 , Hugo Critchley 1 , Mara Cercignani 1,3 , and Neil Harrison 1
1
Clinical Imaging Sciences Centre, Brighton &
Sussex Medical School, Brighton, Sussex, United Kingdom,
2
Department
of Psychiatry, University of Cambridge, Cambridge,
United Kingdom,
3
Neuroimaging
Laboratory, IRCCS Santa Lucia, Italy
Reward processing is dependent on dopaminergic activity,
and it has been found to be affected in
attention-deficit hyperactive disorder (ADHD). In this
fMRI study, we seek to establish the effect of
dopaminergic medication on novelty processing and reward
prediction in ADHD. Patients were scanned twice, on
their usual medication and on placebo. Participants
engaged in a three-armed bandit task with novelty
manipulation, and their choices were fitted by a
temporal-difference learning model to estimate their
prediction error. The activity of the ventral-striatum
correlated with the prediction error, with preliminary
evidence suggesting that such activity is modulated by
the drug.
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