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Abstract #3481

Impact of Different Mental States on Low-frequency Functional Fluctuation

Xue Zhang 1 , Qianqian Zhang 1 , Xiaoyue Chen 2 , Xuesong Li 3 , and Lihong Wang 1

1 Center for Biomedical Imaging Research, Tsinghua University, Beijing, Beijing, China, 2 Department of Psychology, Tsinghua University, Beijing, Beijing, China, 3 Department of Biomedical Engineering, Tsinghua University, Beijing, Beijing, China

How different mental states impact on resting state functional fluctuation is a big concern for clinical application of resting state fMRI. In this study, we induced restful mental state using a mindful breathing task and stressful mental state using two stressful tasks, the mathematic mental loading task and speech preparation task. Our results revealed significant changes in resting-state low-frequency fluctuation (ALFF) post versus pre each of these tasks. The changes were not contributed to test-retest reliability, which warrants careful interpretation of resting state fMRI results.

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