Abstract #3482
microstructural brain abnormalities in patients with major earthquake-induced posttraumatic stress disorder: a diffusion tensor imaging study
Lei Li 1 , Du Lei 1 , Xueling Suo 1 , Fenglai Xiao 2 , Min Wu 1 , Xiaoqi Huang 1 , and Qiyong Gong 1
1
Huaxi MR Research Center (HMRRC), Department
of Radiology, West China Hosipital of Sichuan
University, Chengdu, Sichuan, China,
2
West
China Hosipital of Sichuan University, Department of
Neurology, Chengdu, Sichuan, China
We included 88 PTSD patients and 91 matched survivors
without PTSD suffering from a severe earthquake for DTI
assessment. Besides voxel-based analysis, we also
conducted an exploratory research by searching for the
correlations between all possible pairs of affected
white matter regions to detect the altered pattern of
interregional correlations of microstructural
abnormalities in PTSD. Our results demonstrated the
white matter abnormality in frontal-temporal system and
putative correlations between these two areas. Moreover,
the absence of positive correlation between prefrontal
regions and precuneus in our results may suggest a
potential disruption of the central executive network in
PTSD patients.
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