Longitudinal functional connectivity changes in Middle Cerebral Artery Occlusion: correlation with diffusion, T2 and behavioral outcomes
Lora Talley Watts 1 , Shiliang Huang 1 , Qiang Shen 1 , Justin Alexander Long 1 , Wei Li 1 , and Timothy Duong 1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States
This study examined longitudinally the rsfMRI changes
following a 45-min MCAO in rats up to 28 days.
Quantitative correlations were made with T2, DTI,
fractional anisotropy (FA), and functional outcomes
(forelimb placement asymmetry and foot fault scores).
rsfMRI z-scores reduced after MCAO but improved with
time. The trend of improvement parallels those of
behavioral scores. rsfMRI did not significantly
correlate with ADC, FA and T2 changes, suggesting they
provide complementary information. This study
demonstrated that rsfMRI offers novel insight into
functional connectivity following MCAO.
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