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Abstract #3485

MRI Detection and Histological Correlates of the Dependence of Brain Damage on Recovery Time Between Recurrent Mild Strokes.

Qinbo Deng 1 , Min Qiao 2 , Tadeusz Foniok 3 , Dave Rushforth 3 , and Ursula I Tuor 2,4

1 University of Calgary, Calgary, Alberta, Canada, 2 Physiology and Pharmacology, University of Calgary, Alberta, Canada, 3 Experimental Imaging Centre, University of Calgary, Alberta, Canada, 4 Cl Neurosciences and Radiology, University of Calgary, Alberta, Canada

Recovery from an initial mild ischemic insult could influence the susceptibility of the brain to a second insult. We assessed brain damage using magnetic resonance imaging and histology comparing brain damage produced by a combination of two mild transient ischemic insults with intervals of either 1 day, 2 day, 3 day or 1 week. A recurrent mild PT enhanced the tissue damage and this enhancement was greater with a short recovery (1-3d) versus a longer recovery (1w) between insults. This indicates that brain is most susceptible to a second mild ischemic insult for several days after a first insult.

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