Abstract #3486
Biomarkers to estimate the time of onset of cerebral ischemia
Carole Berthet 1 , Lijing Xin 2 , Corine Benakis 1 , Rolf Gruetter 2,3 , Lorenz Hirt 1 , and Hongxia Lei 4,5
1
Department of Clinical Neurosciences, Centre
Hospitalier Universitaire Vaudois, Lausanne, Vaud,
Switzerland,
2
LIFMET,
cole Polytechnique Fdrale de Lausanne, Vaud,
Switzerland,
3
Univesity
of Lausanne, Vaud, Switzerland,
4
CIBM-AIT,
cole Polytechnique Fdrale de Lausanne, Lausanne,
Vaud, Switzerland,
5
University
of Geneva, Geneva, Geneva, Switzerland
Thrombolysis, the only currently available treatment for
ischemic stroke can be administered only in a narrow
time window of 4.5 hours. A significant number of
patients have an unknown time of onset as the stroke
occurred during their sleep, which disqualifies them for
thrombolysis. The objective of this study was to
determine whether 1H MRS of the ischemic striatum could
provide useful information on the estimation of the
onset time of cerebral ischemia.
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