Abstract #3493
Resting-State Functional Connectivity in Fronto-Striatal Networks during Abstinence Predicts Cocaine Consumption after Relapse: Results from a fMRI Study on Awake Non-Human Primates
Kaundinya Gopinath 1 , Kevin Murnane 2 , Eric Maltbie 2 , and Leonard Howell 2,3
1
Department of Radiology & Imaging Sciences,
Emory University, Atlanta, GA, United States,
2
Yerkes
National Primate Research Center, Emory University,
Atlanta, GA, United States,
3
Department
of Psychiatry and Behavioral Sciences, Emory University,
Atlanta, GA, United States
Cocaine addiction is characterized by alternating cycles
of abstinence and relapse and loss of control drug
consumption. We examined three female rhesus monkeys in
prolonged abstinence following a long history of cocaine
consumption with resting state fMRI. The results showed
that acute cocaine administration selectively impaired
top-down prefrontal circuits that control behavior while
sparing connectivity of striatal areas within circuits
related to cocaine abuse. Importantly, impaired
connectivity between prefrontal and striatal areas
during abstinence predicted cocaine consumption during
relapse. Thus, loss of fronto-striatal connectivity may
be a critical mechanism underlying the cycles of
abstinence and relapse that characterize cocaine
addiction.
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