Abstract #3494
Reduced magnetization transfer in gray and white matter in the developing Fmr1 knockout mouse
Da Shi 1,2 , Su Xu 1 , Jiachen Zhuo 1 , Mary C. McKenna 2,3 , and Rao P. Gullapalli 1,2
1
Department of Diagnostic Radiology and
Nuclear Medicine, University of Maryland School of
Medicine, Baltimore, MD, United States,
2
Department
of Biochemistry and Molecular Biology, University of
Maryland School of Medicine, Baltimore, MD, United
States,
3
Department
of Pediatrics, University of Maryland School of
Medicine, Baltimore, MD, United States
Fragile X syndrome (FXS) is the most commonly inherited
form of mental retardation and effects 1:5000 males.
Magnetic resonance imaging and spectroscopy has only
recently employed to study FXS and the
Fmr1
-/-
mouse
model. Magnetization transfer (MT) imaging in both gray
and white matter regions of the developing
Fmr1
-/-
mouse
revealed reduced MT ratio compared to wild type
controls. The reduction of MT ratio in the developing
Fmr1
-/-
mouse
in white matter may reflect a delay in myelination,
while reduction in gray matter may indicate decrease in
protein concentration.
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