Abstract #3495
Abnormalities in brain structure and biochemistry associated with mdx mice measured by in vivo MRI and high resolution localized 1 H MRS
Su Xu 1 , Da Shi 1 , Stephen JP Pratt 2 , Wenjun Zhu 1 , Andrew Marshall 1 , and Richard M Lovering 2
1
Department of Diagnostic Radiology and
Nuclear Medicine, University of Maryland School of
Medicine, Baltimore, MD, United States,
2
Department
of Orthopaedics, University of Maryland School of
Medicine, Baltimore, MD, United States
Duchenne muscular dystrophy (DMD) is an X-linked
disorder characterized by progressive wasting of
skeletal muscles and, in some patients, cognitive
impairment. DMD is caused by the lack of dystrophin. To
date the knowledge about dystrophin function is derived
from studies of dystrophin-deficient animals, with the
most common model being the
mdx
mouse.
We studied the brains of one-year-old
mdx
mice
in
vivo
and
report enlarged lateral ventricles and elevations in
glutathione and taurine in the hippocampus. Such
findings indicate a structural change, an altered
cellular antioxidant defenses and a perturbed
osmoregulation in the brain due to the lack of
dystrophin.
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