Abstract #3498
Longitudinal monitoring of transverse relaxation time changes in the corpus callosum of a mouse model of Alzheimers disease
Firat Kara 1,2 , Reinhard Schliebs 3 , Stephan Roner 3 , Annemie van der Linden 1 , Huub J.M. Groot 2 , and A. Alia 2,4
1
Bio-imaging Lab, Biomedical Sciences,
University of Antwerp, Antwerp, Belgium,
2
Leiden
Institute of Chemistry, Gorlaeus Laboratoria, Leiden
University, Leiden, Netherlands,
3
Paul
Flechsig Institute for Brain Research, Leipzig
University, Leipzig, Germany,
4
Institute
of Medical Physics and Biophysics, Leipzig University,
Leipzig, Germany
In this longitudinal study, we monitored in vivo
magnetic resonance transverse relaxation time (T2)
changes in the corpus callosum of the Tg2576 mouse model
of Alzheimer's disease at 10, 12, 16, and 18 months of
age. Our results showed significant elongation of in
vivo T2 values in the corpus callosum of Tg2576 mice
compared to wild-type mice at all studied ages. Our
results suggest that demyelinating and inflammatory
pathology may lead to prolonged relaxation times and can
mark an early event during AD progression. To our
knowledge, this is the first longitudinal in vivo T2
study assessing microstructural changes in the CC of the
Tg2576 mice.
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