Abstract #3499
Different responses to acute administration of a new 5-HT7 receptor agonist as a function of adolescent pre-treatment: a phMRI study
Luisa Altabella 1 , Francesca Zoratto 1,2 , Giovanni Laviola 1 , Walter Adriani 1 , and Rossella Canese 1
1
Cell Biology and Neurosciences Dept.,
Istituto Superiore di Sanit, Rome, Italy,
2
Bambino
Ges Children's Hospital IRCCS, Rome, Italy
LP211 is a selective agonist of serotonin receptor 7
(5-HT7) that shows consistent psychoactive effects onto
exploratory motivation, anxiety-related profiles, and
spontaneous circadian rhythm. Using pharmacological MRI,
we detected different responses to acute LP211 in adult
rats as function of a previously adolescent treatment
with the same drug, possibly due to modification of
5-HT7 receptor distribution and/or level of expression
as well as potential rearrangement of forebrain
networks.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
