Abstract #3499
Different responses to acute administration of a new 5-HT7 receptor agonist as a function of adolescent pre-treatment: a phMRI study
Luisa Altabella 1 , Francesca Zoratto 1,2 , Giovanni Laviola 1 , Walter Adriani 1 , and Rossella Canese 1
1
Cell Biology and Neurosciences Dept.,
Istituto Superiore di Sanit, Rome, Italy,
2
Bambino
Ges Children's Hospital IRCCS, Rome, Italy
LP211 is a selective agonist of serotonin receptor 7
(5-HT7) that shows consistent psychoactive effects onto
exploratory motivation, anxiety-related profiles, and
spontaneous circadian rhythm. Using pharmacological MRI,
we detected different responses to acute LP211 in adult
rats as function of a previously adolescent treatment
with the same drug, possibly due to modification of
5-HT7 receptor distribution and/or level of expression
as well as potential rearrangement of forebrain
networks.
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