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Abstract #3499

Different responses to acute administration of a new 5-HT7 receptor agonist as a function of adolescent pre-treatment: a phMRI study

Luisa Altabella 1 , Francesca Zoratto 1,2 , Giovanni Laviola 1 , Walter Adriani 1 , and Rossella Canese 1

1 Cell Biology and Neurosciences Dept., Istituto Superiore di Sanit, Rome, Italy, 2 Bambino Ges Children's Hospital IRCCS, Rome, Italy

LP211 is a selective agonist of serotonin receptor 7 (5-HT7) that shows consistent psychoactive effects onto exploratory motivation, anxiety-related profiles, and spontaneous circadian rhythm. Using pharmacological MRI, we detected different responses to acute LP211 in adult rats as function of a previously adolescent treatment with the same drug, possibly due to modification of 5-HT7 receptor distribution and/or level of expression as well as potential rearrangement of forebrain networks.

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