Nootropics prevent the effect of scopolamine in an phMRI provocation model

The effective treatment of cognitive decline is still a major challenge of the drug research. Scopolamine based small animal phMRI provocation model can be a suitable translational method for testing new compounds. Scopolamine strongly decreased the BOLD responses in the PFC but had no visible effect in other brain areas. Scopolamines effect could be fully prevented with the donepezil pretreatment, whereas vinpocetin and piracetam caused a partial reversal of the BOLD responses only. The new vinpocetin derivative RG compound exerted partial effect also, but its effective dose was much lower than that of the reference compound donepezil.

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