Abstract #3501
Hypoglycemia activation of cerebral blood flow is mediated by glucose transporter isoform 2: an in vivo CASL study
Hongxia Lei 1,2 , Frederic Preitner 3 , Bernard Thorens 3 , and Rolf Gruetter 2,3
1
University of Geneva, Geneva, Geneva,
Switzerland,
2
CIBM-AIT,
cole Polytechnique Fdrale de Lausanne, Lausanne,
Vaud, Switzerland,
3
University
of Lausanne, Vaud, Switzerland
Glucose is essential to maintain normal brain function
and glucose transporters (GLUTs) are key elements to
facilitate glucose supplies in brain. The aim is to
study the roles of GLUT isoform 2 (GLUT2) on
hypoglycemia activation of cerebral blood flow (CBF) by
investigating mice without expressing GLUT2 (GLUT2-/-)
using one of perfusion imaging techniques, the CASL
technique, at 9.4T. The diminished CBF responses upon
hypoglycemia in these mice suggested that GLUT2 mediated
hypoglycemia activation of CBF.
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