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Abstract #3501

Hypoglycemia activation of cerebral blood flow is mediated by glucose transporter isoform 2: an in vivo CASL study

Hongxia Lei 1,2 , Frederic Preitner 3 , Bernard Thorens 3 , and Rolf Gruetter 2,3

1 University of Geneva, Geneva, Geneva, Switzerland, 2 CIBM-AIT, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 3 University of Lausanne, Vaud, Switzerland

Glucose is essential to maintain normal brain function and glucose transporters (GLUTs) are key elements to facilitate glucose supplies in brain. The aim is to study the roles of GLUT isoform 2 (GLUT2) on hypoglycemia activation of cerebral blood flow (CBF) by investigating mice without expressing GLUT2 (GLUT2-/-) using one of perfusion imaging techniques, the CASL technique, at 9.4T. The diminished CBF responses upon hypoglycemia in these mice suggested that GLUT2 mediated hypoglycemia activation of CBF.

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