Mapping Gd-DOTA leakage kinetics in experimental cerebral malaria

Increased permeability of the blood-brain barrier has been suggested as one of the pathophysiological mechanisms in cerebral malaria, an encephalopathy caused by Plasmodium infection. Here, we quantified the spatial and temporal occurrence of endothelial permeability to Gd-DOTA in vivo during progression to cerebral malaria in a mouse model using dynamic MRI at 11.75T. Abnormal permeability appeared simultaneously with the first clinical signs and was quantitatively related to their severity. Spatial differences were observed with olfactive regions displaying the highest permeability. Quantitative mapping of the endothelial permeability by MRI can be used for follow-up and treatment monitoring.

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