Quantitative relaxometry reveals the early involvement of rostral white matter tracts in a murine model of cerebral malaria

Although some anatomical abnormalities can be observed on conventional MRI in cerebral malaria, they lack pathological specificity and are not easily quantifiable. To further characterize a murine model of cerebral malaria we acquired quantitative T1 and T2 maps at 11.75T. The maps display significant increase in T2 and T2* in white matter tracts, notably in the olfactory limb of the anterior commissure preceding the occurrence of more caudal lesions. Although challenging at high magnetic field, quantitative mapping of relaxation parameters may provide sensitive markers of disease progression and help elucidate the underlying pathophysiological mechanism.

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