Abstract #3505
Blood-Brain Barrier Stabilization Effects of Agmatine Assessed by Dynamic Contrast-Enhanced MRI in a Rat Model of Transient Cerebral Ischemia
Sung Soo Ahn 1 , Se Hoon Kim 2 , Jong Eun Lee 3 , Kook Jin Ahn 4 , Dong Joon Kim 1 , Hyun Seok Choi 4 , Seung-Koo Lee 1 , and Yoon Seong Choi 1
1
Radiology, Yonsei University College of
Medicine, Seoul, Seoul, Korea,
2
Pathology,
Yonsei University College of Medicine, Seoul, Korea,
3
Anatomy,
Yonsei University College of Medicine, Seoul, Korea,
4
Radiology,
The Catholic University College of Medicine, Seoul,
Korea
This study is about quantitative evaluation of
blood-brain barrier stabilization effect of agmatine in
rat models of transient cerebral ischemia using dynamic
contrast-enhanced MRI at early stages to reduce the
complications associated with thrombolytic therapy in
ischemic stroke, and demonstrated the feasibility of
DCE-MRI for the investigation of new therapies.
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