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Abstract #3506

Hippocampus is sensitive to hypoxia ischemia in neonatal rat: an in vivo magnetic resonance spectroscopy study

Su Xu 1,2 , Jaylyn Waddell 3 , Da Shi 1,2 , Wenjun Zhu 1,2 , Andrew Marshall 1,2 , Rao Gullapalli 1,2 , and Mary C McKenna 3

1 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Core for Translational Research in Imaging @ Maryland, Baltimore, MD, United States, 3 Department of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, United States

A key requirement for developing efficient therapies to treat the perinatal hypoxic ischemia (HI) is to identify alterations that occur following a brain insult at early stages of brain development. The present study evaluated the regional brain metabolic alterations from moderate neonatal HI rats that were followed up to 28 days after initial injury using in vivo high resolution 1 H MRS. Severe oxidative, osmotic stress, impaired oxidative phosphorylation, and consequent reliance on anaerobic glycolysis were found in the ipsilateral hippocampus. The results indicate that the developing hippocampus is sensitive to HI which may have a profound impact on neurodevelopment.

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